Pioglitazone For Nerve Healing?

    • vgau863
      August 15, 2020 at 3:17 pm

      Has anyone asked their neuro about the drug Pioglitazone? Studies suggest Its supposed to help heal nerve damage. Anyone take it to promote nerve healing?

    • Jim-LA
      August 15, 2020 at 6:08 pm

      Please be aware the U.S. Food and Drug Administration (FDA) has informed the public that use of the diabetes medication Actos (Pioglitazone) for more than one year may be associated with an increased risk of bladder cancer.

      Pioglitazone can be used to treat Diabetic Peripheral Neuropathy (DPN) and there is a Clinical Trial still open for it. The trial has not been updated since 2016 and is either still awaiting results or abandoned. However, the lead Dr. overseeing the trial has published a recent paper with some results. Details can be viewed here:
      https://clinicaltrials.gov/ct2/show/study/NCT02887625
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312325

      There are no Clinical Trials using Pioglitazone to treat CIDP/GBS.

      Perhaps a better alternative for repairing nerve damage can be found in the following thread:

      Can CIDP Cause HIGH Vitamin B-12 Value

    • vgau863
      August 15, 2020 at 9:37 pm

      Thanks Jim. This is the link where I got the information.

      https://link.springer.com/article/10.1007/s00401-020-02179-x?fbclid=IwAR3dthAcQnAA4ZpDi8SX4VflPIcl8TOUPODumDQTCuDOn4E7mBdXburt1Z4

    • Jim-LA
      August 15, 2020 at 10:06 pm

      According to the article you posted: the application of Pioglitazone to DRG neurons did not significantly alter the anterograde and retrograde transport of lysosomes within unmyelinated axons. Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy. It appears there are no human studies as of yet. Maybe they will establish a Clinical Trial soon?

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