Irritated veins from IVIG?

    • March 15, 2013 at 2:50 am

      Hello all! I hope everyone is doing ok.. I am almost 2 years into the whole IVIG thing and maintaining pretty well. We have been spreading out my IVIG to every 3 weeks.. though I think I probably need it every 2, but my veins are really irritated.. they are thinmking about adding immunosuppresants..   Anyhow does anyone else have this problem?? I have tenderness of the vein after infusion- all the way up my arm.. and my leg veins also get inflammed (DVT’s have been ruled out btw)..  I take NSAIDs to help, but just curious if anyone else has this reaction – I have been able to increase my rate as my body otherwise seems to have adapted to IVIG better in a lot of ways.. Thanks so much in advance!

    • March 15, 2013 at 6:41 pm

      I had the same irritation in the beginning.  We were running fast and several times had to changer site because of vein irritation.  We now do IVIG at a maximum of 50 ml per hour and have no vein or site irritation.  You might try slowing down.

    • March 20, 2013 at 3:10 pm

      Thanks so much!!! I will have them slow it down.. How much saline do you get after the infusion?? I used to get 150 I believe, but due to the infusion taking so long, we have cut it back to 50-75 in the past several infusions.. I wonder if that has anything to do with it?? They said I could cut it out completely, but I feel like it washing out my veins is a good thing!

    • March 20, 2013 at 5:45 pm

      We don’t flush with saline as immune globulin “does not like saline” and calls for dextrose flush and we just flush with enough to clear the lines.

      go to
      Post Administration


      Flush IV line with 5% dextrose in water (D5W) or co
      solution following the transfusion.


      Disconnect the IVIG administration set.


      Document post transfusion information on the compat
      label/tag and recipient’s chart following completio
      n of the


      Return the laboratory portion of the compatibility
      label/tag to the
      Transfusion Laboratory according to policy.


      Monitor the recipient for at least 30 minutes after
      the transfusion.


      Dispose of IVIG product bottles or containers and t
      ubing in
      compliance with standard precautions according to h
      ospital policy
      and procedure.

    • March 21, 2013 at 1:14 am

      Thanks Bill!   So, funny you mention that about the D5/saline issue.. I noticed at my infusion on monday that they just hooked the saline right up to my iv after my ivig.. I realized then that they hadn’t used D5 to flush the past several infusions.. I asked about it, and they said that just a few months back it came out that it was now ok/compatible to use saline with the gammunex and you dn’t have to flush with D5 in between.. I wasn’t sure if i should believe this or not, as I don’t have a ton of faith in the infusion people from past experience, so wasn’t sure if they were just telling me that due to htem forgetting- have you heard anything like that – that the compatability has now been disproven?

    • GH
      March 21, 2013 at 2:05 am

      Bill, I don’t see globulin “does not like saline” in that document, or any indication that IvIg is not compatible with normal saline. Whom are you quoting?

      Either dextrose (d-glucose) or normal saline is given intra venously because they are compatible with the blood. I don’t see how saline could be a problem since the blood is saline.

    • GH
      March 21, 2013 at 2:13 am

      Here is the data sheet on Gamunex-C. It is mixed with dextrose for dilution, but the line may be flushed with either dextrose or saline solution.