CIDP and Gamunex-C Dosage

- Bugintn
  
  September 8, 2021 at 2:36 pm
  
  Hi,
  
  Question for medical professionals and patients. Gamunex-C and the ICE trials suggest 2G/KG for the intial treatement and 1G/KG after. I have been told that the KG is body weight and ideal weight. If the prescription is based on ideal weight and there is a signifiant difference between the acutal body weight and ideal weight, the outcome of the treatment is not 2g. It is common that the neuro is prescribing based on Ideal weight and would that not heavily skew the trial outcome?
- David Tuck
  
  September 8, 2021 at 3:09 pm
  
  Good afternoon, as a patient with CIDP as well as an acute care clinical pharmacist we dose many drugs based on adjusted lean body weight vs. ideal body weight, or actual body weight. It does however depend on the pharmacodynamics and pharmacokinetics of the drug including volume of distribution in various tissues and fluids. That being stated, adjusted lean body weight is for patients who have total body weight 30% or greater than their lean body weight or ideal body weight. The difference between the two multiplied by 0.4 and added to the patient’s lean or ideal body weight. This is more a pharmacist and researcher type calculation and not necessarily common practice amongst physicians.
- Jim-LA
  
  September 8, 2021 at 5:00 pm
  
  Here is a handy dosage calculator for IVIg and SCIg:
  
  https://pbco.ca/IVIG_Dosing_Calculator.htm
- Bugintn
  
  January 24, 2022 at 10:49 pm
  
  Thank you for the information. I failed to send this earlier.