Vyvgart to treat CIDP

    • January 3, 2024 at 3:17 pm

      Hello – has anyone been treated with Vyvgart for their CIDP? My neurologist is pushing this treatment and I can’t really find much about using Vyvgart for CIDP. It is approved to treat gMG. I am worried to go on a drug like this because it causes your immune system to be weaker and you can end up with other infections (common UTI and Upper Resp Infections). I currently get IVIG every 5-6 weeks and have no symptoms or problems with my treatment. I am trying to find out more about Vyvgart and CIDP before my next appointment with my neurologist so I am armed with information. Any information would be greatly appreciated.

    • January 3, 2024 at 3:58 pm

      Hello Chrpybirdy,
      <div>I have CIDP as well and understand your dilemma. Argenx has ongoing studies for use of efgartigimod alfa (Vyvgart)for use in CIDP. They also have a version with hyaluronidase. It antagonizes the neonatal Fc receptor reducing circulating Ig including autoantibodies). The thought is it will reduce or eliminate the bad Ig that attacks your nerve junctions that causes the untoward effects caused by CIDP. The hope is it will be equally as effective as Ig (IV or SubQ) or better. You are correct that Vyvgart is currently only approved in the US for Myasthenia Gravis (MG). You might want to contact Argenx USA to gather more information.  I believe many of us are awaiting to see what results the phase two trials show and see it move into phase three. You can also reach out to one of the physician specialists at a center of excellence listed on the GBS-CIDP Foundation web-site and email them a question regarding this novel agent.  Good luck on your journey and hopefully this is helpful.</div>
      <div>Dave Tuck, PharmD</div>

    • January 8, 2024 at 8:02 pm

      Thanks, Chirpy and David! I  have pure sensory CIDP, saw my neurologist last week, she was pushing the same drug and I had the same questions and concerns. Seems like it’s far too soon to leap. I’ve been referred to a neuromuscular clinic and will see what they have to say. Meanwhile, will be watching this space. Thanks again.

    • June 24, 2024 at 11:57 pm

      I also had pure sensory cidp > 8 years and i had no detailed info regarding Vyvgart.

      hope soon u can have a clear data or any one can share experience.