Does the amount of protein in a CSF determine the amount of IVIg you get?
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Does the amount of protein in a CSF determine the amount of IVIg treatment you get?
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As far as I know, whatever info they derived from my Lumbar Puncture / Cerebral spinal fluid collection, it did not go into the IG dosing consideration.
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If, by “amount of IVIG…” you are referring to the initial loading dose and subsequent follow up doses the answer is no. The dosing for IVIG products is spelled out in the Manufacturer’s Prescribing Information Data Sheet and, in most cases, has been approved by the FDA.
See: https://www.fda.gov/downloads/BloodBloodProducts/ucm069968.pdf
The amount of IVIG given is generally given based on body weight. For example from an article by the National Institutes of Health (NIH) “The usual initiating dose of intravenous immunoglobulins (IVIg) in the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) is 2 g/kg/course.”
This means that if you weigh 50 kg, approx 100 lbs, you would be given 2 x 50 =100g as a loading dose.
Of course the dose, and the actual infusion rate, you receive is determined by your doctor.
You might benefit by reviewing some of the resources available on this site if you have not already. For example https://www.gbs-cidp.org/cidp/all-about-cidp/
Explore the various tabs on this website to learn about this condition.
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Not for me. My CSF was not elevated (it is not in 20% of CIDP cases per my neuro). I received a typical 2g/kg loading dose over 4 days, then 1g/kg loading doses for subsequent months. Just my experience.
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The dosing is actually based on ideal body weight. A person who is greatly overweight should not be receiving a dose based on actual weight.
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