I have always recieved 50mg solumedrol and 50mg diphenhydramine (sp?) as pre-meds. headaches are usally due to infusion rate. slower the better. i max at 160mg/hr. also, infrequent, multi-day “blasts” are old school treatment for CIDP. maintenance doses should be single infusions. I have been as frequent as twice weekly (about every 3 days) and am now tapering down to every other week. it’s not as hard on the body and you have a more leveled off, stable amount of IVIG in your body. It’s like so many medications where you have to maintain a therapeutic level in your bloodstream for best results. I still don’t know why so many neurologist don’t get that?