New to the forum here trying to educate myself on new, progressive treatments. After 4+yrs of IVIG and slowly getting worse CIDP (37 yrs old and functioning well), I wanted to try something new, so Plasma Exchange it was. I went in for the first of 5 consecutive treatments over the course of a week and a half. The first one was done 3 weeks after IVIG and I felt worse the next day. The second treatment followed 2 days later. The following day I was unable to walk, and about 80-90% of my body was severely numb. I could not get up without assistance and was a very downward trajectory following one of the best months I had had in several years. Needless to say, the PE had a strong adverse effect on me and 2 months later I still haven’t recovered. There must have been good things taken out of my system, which set me back. I hope to recover by increasng my IVIG dose to get back to “normal.”