Influenza Vaccination in Adults

Guillain-Barré Syndrome After Influenza Vaccination in Adults
A Population-Based Study

David N. Juurlink, MD, PhD; Therese A. Stukel, PhD; Jeffrey Kwong, MD, MSc; Alexander Kopp, BA; Allison McGeer, MD, MSc; Ross E. Upshur, MD, MSc; Douglas G. Manuel, MD, MSc; Rahim Moineddin, PhD; Kumanan Wilson, MD, MSc

Arch Intern Med. 2006;166:2217-2221.

ABSTRACT

Background Whether influenza vaccination is associated with Guillain-Barré syndrome (GBS) remains uncertain.

Methods We conducted 2 studies using population-based health care data from the province of Ontario, Canada. In the first study, we used the self-matched case-series method to explore the temporal association between probable influenza vaccination (adults vaccinated during October and November) and subsequent hospitalization because of GBS. In the second study, we used time-series analysis to determine whether the institution of a universal influenza immunization program in October 2000 was associated with a subsequent increase in hospital admissions because of GBS at the population level.

To see the article cut and past the link minus the quote marks.
“http://archinte.ama-assn.org/cgi/content/full/166/20/2217”