Prednisone is converted by the liver to prednisolone, which is what I think they administer by IV. It is therefore likely harder on the liver than IV administration. Because prednisone can cause stomach upset directly, oral prednisone is likely harder on it than IV administration. However, if you check liver function frequently and control stomach upset (prednisone with food), it seems to be a good option. Work closely, though, with your neurologist, because each of us differs in our response.
Thanks for the follow up information Mark. I am saving your comments.