Reply To: Experience with amitriptyline / tricyclic antidepressants?

February 17, 2013 at 4:56 am

Hello Willem,

I used nortriptyline, similar to amitriptyline, for my neuropathic pain early on. A 50 mg dose definitely helped the pain. I experienced the usual side effects of sleepiness and feeling a bit slow mentally, but I was adjusting to them. The side effect that made me switch to gabapentin was the loss of the ability to taste “sweet”. I could still taste bitter, salt, sour, and umani, just not sweet. Note that this side effect is rare; my neurologist had never encountered it before.

If you use the two together, make sure that you have a plane to deal with more sleepiness and minor loss of mental acuity.

Godspeed in your treatment plan.