Question and comment

March 23, 2008 at 12:44 pm

Did you get methylprednisolone 1 gram over 5 days or 1 gram per day for 5 days? I have never seen anyone get the latter–3 gram at 1 g/day for 3 days is the most I have ever seen anyone get. Solumedrol (methylprednisolone) works pretty quickly so if you got really high doses (>1 g) and are not better, consideration of alternative treatment should be made like IV IgG. This is also very likely the case if you got a total of 1 gram over the five days, but you might want to wait a few days to make sure that response is not delayed. I am not sure if you mean that it is a week from the start of the 5 days of solumedrol or the end. If the end, it did not work enough. Because of the way CellCept and Immuran work, they are slow to make a difference and so you have to take them for a while before their effects kick in.

I am like Gene in that it seems a little concerning that you started CellCept and Imuran both at the same time, both at moderate doses (assuming that your kidneys work well). This doctor is really aggressive to give you all this, but many would have chosen either CellCept or Imuran and then pushed that dose up to a higher level if needed to maintain control of the CIDP. The problem may be that you get cumulative side effects from both of these especially perhaps low blood counts and infections with being on these doses of all three from the beginning.

The more I read about autoimmune diseases, the more important it seems to me to get control of the process aggressively (for CIDP with IV IgG or steroids) and then use something to maintain the immune system in a controlled manner (which seems better done with IV IgG or an immunosuppressant medicine).

WithHope for Cure of these diseases.