not as ‘unknown’ as they/you think.

April 30, 2007 at 8:43 am

Keith.[QUOTE]If you have CIDP and MGUS, it doesn’t really seem to tell them anything significant about the CIDP, although it is interesting.[/QUOTE] The question is that it may mean that you have a neuropathy similar to CIDP in its symptoms that may be caused by the MG – monoclonal gammopathy or paraprotein. Usually known, certainly in Europe, as PDN or Paraproteinaemic Demyelinating Neuropathy. My web site about this is with my signature.
In the case of some of the PDN it is now understood how it happens.

Hence Allaug’s explanation.[QUOTE]In my case the MGUS causes the nerve damage, because the IgM produced by the abnormal number of B-cells binds to a protein called MAG (Myelin Associated Glycoprotein), part of the myelin sheath that can be described as the insulation around the nerves, marking it for the macrophages to destroy like they do when a bacteria or virus invade the body.[/QUOTE] Better to ignore the US! It is the monoclonal gammopathy that is significant.

For about 50% of those with IgM but without the anti-MAG element plus those with IgG or IgA it is the case that the explanation is as yet unknown but it is suspected that some other factor as with Allaug’s may be the cause.

Mine is the rarest of these – the IgA one and with mainly sensory damage. Remarkably I met another IgA sufferer at the UK GBS SG conference 9 days ago, having overheard his conversation with the famous Prof Richard Hughes and the keyword ‘paraprotein’! He has much motor damage.:cool: