Polyclonal increase in gamma globulins

    • Anonymous
      June 15, 2010 at 7:58 pm

      I have a question re: interpreting some blood work. My husband has CIDP–MADSAM. The doctor has done serum protein blood tests twice on him. Both times the tests come back with the pathologist’s comment: “Polyclonal increase in gamma globulins, with no monoclonal-type bands seen. No other abnormality noted.” The normal gamma globulin are 7-14 g/L, and my husband’s are 19. Can anyone tell us what this means? Hubby didn’t ask the doctor last time when they were elevated–just picked up the requisition to repeat and didn’t ask any questions. Thanks in advance.
      Laurel
      PS the reason the test got ordered was hubby complained of profuse sweating with minor exertion.

    • Anonymous
      June 17, 2010 at 10:42 am

      Hey Laurel – I believe polyclonal gammopathies are caused by an inflammatory process. I would think the blood test just shows he still has inflammation going on from the CIDP.

      Kelly

    • Anonymous
      June 17, 2010 at 11:35 am

      Thanks Kelly. That makes good sense. I have been googling trying to find the tie in to CIDP and IVIG. So little comes up, but I did find one reference to it as an indicator of autoimmune diseases. Once again, thank you.
      Laurel

    • Anonymous
      June 17, 2010 at 12:01 pm

      You’re welcome Laurel. It’s good to know all of my hours spent on Google can be useful sometimes, LOL.

      Kelly