lyrica old forum from cg – rebuild

    • Anonymous
      May 26, 2006 at 10:44 am

      This is G o o g l e’s cache

      canuckgirl1
      Senior Member

      Registered: Nov 2003
      Location: Canada
      Posts: 238
      Lyrica/Pregabalin

      Hello,

      With today’s approval in Canada and the USA of Pfizers new drug specifically for neuropathic pain, “Lyrica”(Pregabalin), I am including a link to a 42 page “Scientific Discussion” paper, that ends with the recommendation of the drug being approved….(based on the risks/benefits)
      Some of it is sloggy reading to get through, but it is quite fascinating and in-depth on details of the drug, from how it is produced to lab testing results….

      [url]http://www.emea.eu.int/humandocs/PD…a/084504en6.pdf[/url]

      best wishes to all for a very happy and healthy 2005!!!

      __________________
      “Obstacles cannot crush me; every obstacle yields to stern resolve.”
      Leonardo da Vinci

    • Anonymous
      May 26, 2006 at 11:00 am

      Gene,
      Provided link unsuccessful: any other options:

      [url]http://www.emea.eu.int/humandocs/PD…a/084504en6.pdf[/url]

    • Anonymous
      May 26, 2006 at 9:16 pm

      oops, sorry. try this one. take care. be well.

      [url]http://www.emea.eu.int/humandocs/PDFs/EPAR/lyrica/084504en6.pdf[/url]

      gene gbs 8-99
      in numbers there is strength

    • Anonymous
      May 27, 2006 at 7:42 am

      Great it works.. Thanks for the information Gene.

    • Anonymous
      May 27, 2006 at 8:02 pm

      Gene,

      Thanks for the link. I spoke to my specialist about Lyrica causing GBS and she said you cant get GBS from Drugs. I am finding Lyrica fantastic for the pain. I have been on it now for 3 weeks and have been able to increase how much I work as the pain is less.

      Thanks for the info
      Debbie

    • Anonymous
      May 27, 2006 at 10:28 pm

      Hi Debbie,
      I am glad the Lyrica is working well for you, but I would respectfully disagree with your physicians conclusion that drugs cannot cause GBS, many, many medications are neurotoxic and can be associated with causing peripheral neuropathy….in any case this is directly from the Pfizer website (the maker of Pregabalin (Lyrica)…..they are the ones that list GBS as an adverse event observed during the clinical trials of Lyrica, albeit a rare adverse effect, but GBS is most definately noted.

      [url]http://www.pfizer.com/pfizer/download/uspi_lyrica.pdf[/url]

      [B][U]Other Adverse Events Observed During the Clinical Studies of LYRICA [/U][/B]:

      [U][B]Nervous System [/B][/U]– [U]Frequent[/U]: Anxiety, Depersonalization, Hypertonia, Hypesthesia, Libido decreased, Nystagmus, Paresthesia, Stupor, Twitching; Infrequent: Abnormal dreams, Agitation, Apathy, Aphasia, Circumoral paresthesia, Dysarthria, Hallucinations, Hostility, Hyperalgesia, Hyperesthesia, Hyperkinesia, Hypokinesia, Hypotonia, Libido increased, Myoclonus, Neuralgia,[B] [U]Rare[/U]:[/B] Addiction, Cerebellar syndrome, Cogwheel rigidity, Coma, Delirium, Delusions, Dysautonomia, Dyskinesia, Dystonia, Encephalopathy, Extrapyramidal syndrome, [COLOR=”Red”]Guillain Barre syndrome[/COLOR], Hypalgesia, Intracranial hypertension, Manic reaction, Paranoid reaction, Peripheral neuritis, Psychotic depression, Schizophrenic reaction, Torticollis, Trismus

      best wishes to you,
      cg

    • Anonymous
      May 28, 2006 at 8:58 pm

      Debbie,

      My neurologist also told me about Lyrica having the side effect of GBS (based on the write up I suppose) but for me I had no other choice for the nerve pain since I seem to be allergic to everything else they tried to prescribe for me. The pain is worse than when I was taking Neurontin – but the added bonus of no chest/heart pain, no blinding migraine headache, no hives/itching or skin infections (etc) seems to be worth the trade off. (Ha, ha)

      Thankfully, Lyrica seems to work for me (have been taking it since March) and recently I have been able to start back on my exercise routine (albeit at half the time and half the intensity as well as half the number of days per week). I am just happy to be able to do something. 🙂

    • Anonymous
      May 28, 2006 at 11:45 pm

      Cg,

      You are no doubt correct because I have seen the specialist today and we discussed the GBS side effect from Lyrica. She did on the phone say that you don’t get GBS from drugs but today she said if it was the case it would be very rare.

      I am in two frames of mind as to whether or not to take it. I commented yesterday to my husband that I was feeling the best I had felt in over 2 years. If I don’t take the Lyrica then the pain will return and I won’t be able to perform my work properly. However the thought of getting GBS again from the meds makes me wonder what to do.

      Anyway thanks again for the info I will ponder over it.

      Regards,
      Debbie

    • Anonymous
      May 29, 2006 at 8:13 am

      hi debbie,

      does this mean neurontin did not work for you? take care. be well.

      gene gbs 8-99
      in numbers there is strength

    • Anonymous
      May 30, 2006 at 1:47 am

      Gene,

      I never tried neurontin mainly due to its cost. The doctor told me it would be about $220 a month (Australian dollars). The lyrica my specialist said was better than neurontin and costs me $120 a month. I put up with the pain during the last 2 years but I wanted to return to work and couldn’t with the pain I was having. I figure the $30 a week the medication costs me will be worth it if I can earn good money working.

      Regards,
      Debbie

    • Anonymous
      May 31, 2006 at 5:04 am

      cg,

      thx for informative post that does say lyrica is a rare cause of gbs. the info she cites is on pg 36 of [url]http://www.pfizer.com/pfizer/download/uspi_lyrica.pdf[/url].

      her original post from the old forum also by coinkydink on pg 36 of [url]http://www.emea.eu.int/humandocs/PDFs/EPAR/lyrica/084504en6.pdf[/url] cites deaths due to lyrica testing.

      here is link to related thread on lyrica [url]http://gbs-cidp.org/forums/showthread.php?t=73&highlight=lyrica[/url]

      take care. be well.
      gene gbs 8-99
      in numbers there is strength