4 hours sounds about right for the first infusion. They start it really really slow and ramp it up very slowly too, to be sure you don’t have a reaction. I think the next ones were more like 2-1/2 to 3 hours.
I actually felt pretty good after the first two treatments, but the nurse on the third day started it “full speed” since I hadn’t had any reaction beside a very mild headache, and that was the time I felt pretty wiped out. Even if you don’t have any reaction, it shouldn’t be started at full rate — I learned this from my home infusion nurse. They can just ramp it up a bit more quickly. I think nurse #3 wasn’t too familiar with administering IVIG; I’m told that it’s something of an “art.”