Studies I found interesting that I’m sharing

September 22, 2007 at 12:21 am

The insufficient reinnervation sounds just like studies of POST POLIO–GOOGLE IT AND SEE!!

Muscle Nerve. 2005 Jan;31(1):70-7. Links
Electrophysiological signs of permanent axonal loss in a follow-up study of patients with Guillain-Barré syndrome.Dornonville de la Cour C, Andersen H, Stålberg E, Fuglsang-Frederiksen A, Jakobsen J.
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark. [email][/email]

The neurophysiological mechanisms for persisting impairment of motor function after Guillain-Barre syndrome (GBS) were assessed in 37 unselected patients 1-13 years after diagnosis. For evaluation of reinnervation and axonal loss, macroelectromyography (macro-EMG) including measurement of fiber density (FD) was performed. Data from neuropathy symptom score, neuropathy disability score, nerve conduction studies, and quantitative sensory examination were ranked and summed to a neuropathy rank sum score (NRSS). The isokinetic muscle strength at the ankle was measured. Signs of axonal loss with increase of either macro motor unit potential (macro-MUP) amplitude or FD occurred in 76% of patients. The macro-MUP amplitude correlated with muscle strength and with NRSS. Patients with evidence of residual neuropathy had increased macro-MUP amplitude and FD as well as decreased muscle strength compared to patients without evidence of residual neuropathy. We conclude that axonal loss takes place in a substantial number of GBS patients and is associated with permanent muscle weakness caused by insufficient reinnervation. Possible patterns of pathology are discussed in relation to the macro-EMG findings.

PMID: 15543551 [PubMed – indexed for MEDLINE]
God bless Dan