Reply To: Prednisone journey blog

May 20, 2012 at 9:50 pm

Here is a little background on prednisone and Solumedrol. Prednisone by itself is useless. However, the liver converts it to prednisolone, which is the active form. Solumedrol is just an infused form of methylprednisolone. Chemically, there only a small difference between the two, as you might guess from the similarity of the names. Pharmacologically, prednisolone is about 80% as effective as methylprednislone (that is why I took 650 mg: it the the closest practical equivalent to 500 mg of methylprednisolone).

Dick, I cannot remember if you have had Solumedrol infusions. If you did and did not suffer too many side effects, then a 650 mg dose of prednisone should not present too many problems. I am not encouraging you to try this protocol (and nobody should until they have consulted with their neurologist, primary care physician, and all other specialists they see), just letting you know there are other options. Another one you might consider is a double dose every other day. Doing so helps keep the adrenal glands from shutting down glucocorticoid production entirely. It might be slightly less tolerable one day, but you should have a better day on the second.

Again, Godspeed with this,
~MarkEns