Overlap of MG and CIDP

August 14, 2011 at 7:45 pm


While I can imagine that one could have both MG and CIDP with variatons in their dominance, I am surprised to read that they are difficult to distinguish. I thought MG was an autoimmune disease in which the acetocholine receptors in the muscles are under attack, preventing the nerve impulses from activating the muscle, while CIDP was an autoimmune disease in which there is both inflammation of the nerves and demyelination. I would think a NCV/EMG study would differentiate the two. In MG, I would expect the EMG results to show compromise, but the NCV would look normal. In CIDP, I would expect the reverse. What am I missing?