IVIG Dose sound right?

March 16, 2011 at 7:07 pm

Nope, it doesn’t sound right.

But, double check with your doctor. Consider Goodney’s dose of 60g where g = grams.

Now compare that with what you put in your post- “500mg.” 500mg = .5g

As noted on this site on many occasions a so-called standard loading, or first time ‘bolus’ dose of IVIG is usually .4g/kg/day for 5 days.

Figure it out? Well 1 kilogram = 2.20462262 lbs. In nice round numbers, if you weighed 176, or so, pounds you would be 80 kg.

.4g times 80 = 32g. 32g per day for 5 days would be a total of 160g. Now that’s for the IVIG ONLY.

Some IVIG products such as Gammunex and Gammagard come in 10% solutions. As it turns out, so does Privigen. Therefore, the total volume of liquid is times ten.

The Privigen website is not a lot of help. Probably because IVIG is not FDA approved for Privigen to advertise as ‘on-label’ use. Privegen does however, recommend a starting infusion rate of .5mg/kg/min for both of their ‘on-label’ approvals.

Again, if you weigh 80 kg, then .5mg/kg*80kg = 40 mg. Even at this rate your dose of 500 mg would take only 13 minutes! I guess your dose is probably higher.

It is often recommended to pre-dose up to one hour before with Benadryl and Tylenol. Again, check with the doctor. And, as Goodney said, drinking lots of water the day before, during and the day after infusion are critical.

good luck.