The cymbalta 60mg worked for me the very first day I tryed it. Yeah, I too was surprised at how fast it started to work…No question about it. I take a 60 in the morning and a 60 at night. It has been about a year now since I have been on it. No side effects as I can tell. LOL I am like someone said here earlier…..”I am on so much medicine I would not know what is causeing side effects and what isn’t”. Well, maybe not the exact words , but the meaning is the same. lol. God bless all my friends on the forum.