Thank you so much for your comments. I did mean CSF protein sorry about the omitted info. As far as Mayo goes, I was slightly disappointed by their dx. My Dr. diagnosed me with ALS before reading my charts or conducting any lab work. The next week after reviewing all the lab work and my lumbar puncture with the high protein, he backed off and said, “Well maybe you don’t have ALS.”!!!!! Anyway, since they were going after the ALS dx I have not had any of the biopsy procedures that you mentioned. I am going to my local neurologist on Friday. I will ask him about these. Otherwise, I do believe that I am getting a very slight boost from the IVIG. My good leg has had a constant stiffness in the calf for about the last 2-3 months. In the last 10 days that stiffness has completely gone away. Thank you so much for the great info. The one thing that I can’t get over is that the medical community is so disconnected with this condition! Thankfully this forum exists to help each other out. Thanks again.