CIDP- Medical Therapies

October 2, 2011 at 1:19 pm

I found this 2009 Johns Hopkins article, [U]Ther Adv Neurol Disord. 2009 July; 2(4): 261–281[/U] interesting for how many therapies reported a benefit:

“[I]…[COLOR=”DarkGreen”]Cyclophosphamide has never been evaluated in randomized controlled trials[/COLOR], but beneficial effects have been reported in CIDP with an intravenous pulse therapy (1g/m2 a month for up to six months) [Good et al. 1998]. According to one case series, high dose cyclophosphamide treatment can also be beneficial in CIDP patients, but there are obviously increased risks related to this treatment, such as neutropenic infections, transient renal insufficiency and alopecia [Brannagan et al. 2002]. The same group also reported a long-term benefit after a median of 2.9 years in clinical and electrophysiological parameters [Gladstone et al. 2005]. Further positive effects have been reported in case studies and smaller series for mycophenolate mofetil [Gorson et al. 2004], cyclosporine [Odaka et al. 2005; Ryan et al. 2000], alemtuzumab [Hirst et al. 2006], methotrexate [Fialho et al. 2006], autologous hematopoietic stem-cell transplantation [Reményi et al. 2007] and a combination of high dose cyclophosphamide and autologous hematopoietic stem cell transplantation [Axelson et al. 2008b]…[/I]”

And, I reckon, almost all of these have been tried by somebody on this Forum.