CIDP dosing & rates

Anonymous
April 24, 2011 at 12:47 pm

[QUOTE=MarkEns]…I think the Peripheral Nerve Society guidelines suggest a “loading” dose of 2 g/kg and maintenance doses of 1 g/kg every 3 weeks as the starting point for treatment.~MarkEns[/QUOTE]

Thank you. Indeed, it is not only the PNS guidelines, it is straight from

GAMUNEX® PRODUCT MONOGRAPH by Talecris Biotherapeutics, Inc.

“[I]Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): GAMUNEX® may be initially administered as a total loading dose of 2 g/kg (20 mL/kg) given in divided doses over two to four consecutive days. GAMUNEX® may be administered as a maintenance infusion of 1 g/kg administered over 1 day (10 mL/kg) or divided into two doses of 0.5 g/kg (5 mL/kg) given on two consecutive days, every 3 weeks.[/I]”

the whole thing:

[url]http://www.talecris.com/ca/documents/Gamunex_SubQ_PM_Clean.pdf[/url]

Note, if you cannot open a pdf document you may download the free reader from Adobe.

In the document they also talk about maximum infusion rate.

“[I]For intravenous use only. It is recommended that intravenously administered GAMUNEX® should initially be infused at a rate of 0.01 to 0.02 mL/kg per minute (1 to 2 mg/kg per minute) for the first 30 minutes. If well-tolerated, the rate may be gradually increased to a maximum of 0.14 mL/kg per minute (14 mg/kg per minute).[/I]”

Can you digest that? Say I weigh 80kg. My goodness, their suggested maximum would be 14mg/kg*80kg per [COLOR=”Red”]minute[/COLOR]=
1120mg per minute! I’d have a stroke or rupture something.