My toes get numb quite often, especially when I’m exercising…but I notice loss of feeling mostly when I give myself a b12 shot in the thing muscle and barely feel it. Sometimes the shot hits a nerve and oh my goodness I about fall over, other times I feel nothing. I also notice my husand has to push down really hard when he massages my back so I can feel it and get relief from flu like symptoms in my muscles. It’s all a pain…but I try to keep positive. There was a time I could hardly move without assistance…at least I’m past that part of the disease.