About small fiber neuropathy

November 12, 2011 at 1:51 am

I asked my neurologist today about small fiber neuropathy (SFN). First, though, a short lesson on nerves. There are several ways to classify nerves, but one way is through size and covering. In this classification, there are three types of peripheral nerves: large fiber nerves, which are always myelinated, and small fiber nerves, some of which are myelinated and some of which are not. The term “small fiber neuropathy”, my neurologist told me, refers to the unmyelinated nerve fibers. If so, then SFN cannot be a subset of CIDP, by definition.

There is some thought that some, but not all, forms of SFN are autoimmune diseases. That would fit with the Sjogren’s.